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(2) although iron chelators and antioxidants have been used to modulate ferroptosis, their therapeutic efficacy remains inadequate, limiting their clinical utility

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455 In addition, ferulic acid improves cognition dysfunction in copper-loaded Wilsons disease rats, suggesting that it reduces hippocampal neuron damage by activating SIRT1-mediated ferroptosis, providing a valuable drug candidate for the clinical treatment of cognitive impairment caused by Wilsons disease

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